PROGRAMME
Sunday, 24 June
| 15:00 |
Registration opens |
| 17:45 |
Opening remarks |
| 18:00-19:00 |
Keynote Lecture Richard Kitsis (New York, USA) Towards a unified model of cell death and its roles in human disease |
| 19:00-20:30 |
Informal buffet |
Monday, 25 June
| 8:30-10:30 |
Session I New techniques in cardiac metabolism |
| 8:30-9:00 |
Juhani Knuuti (Turku, Finland) Metabolic imaging using PET |
| 9:00-9:30 |
Jurgen Schneider (Oxford, UK) 1H-MR spectroscopy for lipid and creatine metabolism |
| 9:30-10:00 |
Damian Tyler (Oxford, UK) Hyperpolarized 13C Magnetic Resonance studies of cardiac metabolism |
| 10:00-10:15 |
Cameron Holloway (Oxford, United Kingdom) HIV is associated with abnormal myocardial fat metabolism and function, revealed using cardiac magnetic resonance |
| 10:15-10:30 |
Adam Nabeebaccus (London, United Kingdom) NADPH oxidase-4 induces metabolic reprogramming in the murine heart in vivo |
| 10:30-11:00 |
Coffee break |
| 11:00-13:00 |
Session II Metabolic signalling in heart failure |
| 11:00-11:30 |
Gary Lopaschuk (Edmonton, Canada) The contribution of altered fatty acid oxidation to heart failure development |
| 11:30-12:00 |
Rong Tian (Seattle, USA) Reduced Complex I function of the mitochondria accelerates heart failure in mice |
| 12:00-12:30 |
Michael Frenneaux (Aberdeen, UK) Metabolic therapies for heart muscle diseases |
| 12:30-12:45 |
Haipeng Sun (Los Angeles, USA) Remodeling of branched chain amino acid metabolism during heart failure |
| 12:45-13:00 |
Lorrie Kirshenbaum (Winnipeg, Canada) Preferential targeting of Bnip3 isoforms to mitochondria or endoplasmic reticulum during metabolic stress of post-natal ventricular myocytes |
| 13:00-14:00 |
Lunch |
| 14:00-15:30 |
Session III Mitochondrial energy metabolism in heart failure |
| 14:00-14:30 |
Charles Hoppel (Cleveland, USA) Title TBC |
| 14:30-15:00 |
Torsten Doenst (Jena, Germany) Mitochondrial adaptations to cardiac hypertrophy |
| 15:00-15:30 |
Michael Sack (Bethesda, USA) Caloric dependent post-translational control of mitochondria in cardiac hypertrophy |
| 15:30-16:00 |
Coffee break |
| 16:00-17:30 |
Session IV Mitochondrial dynamics, biogenesis and autophagy |
| 16:00-16:30 |
Roberta Gottlieb (San Diego, USA) Mitophagy and cardioprotection |
| 16:30-17:00 |
Joseph Hill (Dallas, USA) Cardiomyocyte autophagy: metabolic profit-and-loss |
| 17:00-17:30 |
Daniel Kelly (Orlando, USA) Transcriptional control of cardiac mitochondrial biogenesis |
| 17:30-19:00 |
Poster Session I (with drinks) |
| 19:00-21:30 |
Dinner Dinner Lecture Lionel Opie (Cape Town, South Africa) Cardiac metabolism - blending the past with the future |
Tuesday, 26 June
| 8:30-10:15 |
Session V Myocardial lipotoxicity – a contributor to heart failure? |
| 8:30-9:00 |
Heinrich Taegtmeyer (Houston, USA) The overfed heart: consequences of increased metabolic pressure |
| 9:00-9:30 |
Margaret Chandler (Cleveland, USA) Metabolic flexibility counteracts lipotoxicity in heart failure |
| 9:30-10:00 |
Gary Sweeney (Toronto, Canada) Direct effect of adipokines on the heart |
| 10:00-10:15 |
Megan Cannon (Groningen, Netherlands) Cardiac-restricted overexpression of liver X receptor attenuates left ventricular hypertrophy by modulating glucose uptake and metabolism |
| 10:15-10:45 |
Coffee break |
| 10:45-11:45 |
Session VI Young investigator award |
| 10:45-11:00 |
Tom Ashmore (Cambridge, United Kingdom) Dietary inorganic nitrate prevents hypoxia-induced electron transport chain dysfunction, energetic impairment and oxidative stress in the rat heart |
| 11:00-11:15 |
Rachel Brewer (Birmingham, USA) Cardiomyocyte circadian clock directly regulates myocardial ketone body metabolism |
| 11:15-11:30 |
Jim Lund (Tromsø, Norway) High and moderate intensity training prevent obesity-related oxygen waste and development of left ventricular dysfunction in the presence of high fat |
| 11:30-11:45 |
Sowndramalingam Sankaralingam (Edmonton, Canada) Lowering body weight in obese mice with heart failure improves insulin sensitivity without worsening cardiac function |
| 11:45-13:15 |
Poster Session II |
| 13:15-14:00 |
Lunch |
| 14:00-16:00 |
Session VII Heart failure development in diabetes and obesity |
| 14:00-14:30 |
Dale Abel (Salt Lake City, USA) Mitochondrial adaptations to obesity and lipid overload |
| 14:30-15:00 |
Linda Peterson (St Louis, USA) In search of the philosopher's stone for obesity and heart failure |
| 15:00-15:30 |
Hildo Lamb (Leiden, Netherlands) MR of the metabolic syndrome |
| 15:30-15:45 |
Heiko Bugger (Freiburg, Germany) Lack of adiponectin receptor 1 impairs mitochondrial function in the heart |
| 15:45-16:00 |
Peter Crawford (Saint Louis, USA) Preservation of redox balance and bioenergetic homeostasis by the ketogenic-ketolytic axis |
| 16:00-18:00 |
Free for sightseeing, college tour, punting |
| 19:00 |
Gala dinner, Blenheim Palace Dinner lecture William Stanley (Baltimore, USA) The zen of the SHVM: if you want to climb a mountain begin at the top |
Wednesday, 27 June
| 8:30-9:30 |
Keynote lecture Peter Ratcliffe (Oxford, UK) Signalling of hypoxia through the HIF Hydroxylase System |
| 9:30-10:30 |
Session VIII Aging and the heart |
| 9:30-10:00 |
Nick Lane (London, UK) A unifying view of ageing and disease |
| 10:00-10:30 |
Peter Rabinovitch (Seattle, USA) Mitochondria, oxidative stress and cardiac aging |
| 10:30-11:00 |
Coffee break |
| 11:00-13:00 |
Session IX Skeletal muscle energetic and exercise in heart failure |
| 11:00-11:15 |
SHVM Business Meeting |
| 11:15-11:45 |
An VanBerendoncks (Edegem, Belgium) The role of adiponectin in chronic heart failure. Focus on skeletal muscle metabolism and effect of exercise training |
| 11:45-12:15 |
P. Christian Schulze (New York, USA) Impaired skeletal muscle metabolism in heart failure |
| 12:15-12:45 |
Ellen Aasum (Tromso, Norway) Diabetic cardiomyopathy - metabolic interventions and exercise |
| 12:45-13:00 |
Anne Hafstad (Tromsø, Norway) High and moderate intensity training prevent diet-induced impairments of cardiac mechanoenergetics and ventricular function |
| 13:00-13:05 |
Concluding remarks |
| 13:05 |
Buffet lunch |
Posters with an odd number are presented during Poster Session 1 (Monday, 25 June, 17:30-19:00). Posters with an even number are presented during Poster Session 2 (Tuesday, 26 June, 11:45-13:15). The recommended poster size is A0 (841 x 1,189 mm; width x height); please be aware that the maximum width available for your poster is 100 cm.
Correct format... 
Wrong format...
P.1 Amira Abd-Jamil (Oxford, United Kingdom)
Regulation of PPARα by HIF-α
|
P.2 Desiree Abdurrachim (Eindhoven, Netherlands)
In vivo magnetic resonance study of cardiac lipid content, energetics, and function in a mouse model expressing malonyl-CoA insensitive Cpt1b
|
P.3 Dunja Aksentijevic (Oxford, United Kingdom)
Mitochondrial function and ATP homeostasis in creatine-free guanidinoacetate-N-methyltransferase (GAMT) knockout mice
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P.4 Michael Allard (Vancouver, Canada)
LKB1 and cardiac adaptation to exercise |
P.5 Paulo A. Amorim (Leipzig, Germany)
Surgical ventricular reconstruction improves cardiac metabolic efficiency after myocardial infarction in rats
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P.6 Yeliz Angin (Maastricht, Netherlands)
Zinc dependent translocation of the fatty acid transporter CD36: involvement of the intracellular cysteines
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P.7 Antonius Baartscheer (Amsterdam, Netherlands)
Chronic activation of PPARα prevents development of hypertrophy and heart failure
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P.8 Adrianus J. Bakermans (Eindhoven, Netherlands)
Myocardial pyruvate dehydrogenase flux in a mouse model of long-chain fatty acid oxidation deficiency
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P.9 Daniel Ball (Oxford, United Kingdom)
Application of hyperpolarized butyrate for real-time assessment of short chain fatty acid metabolism in the rat heart
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P.10 Vicky Ball (Oxford, United Kingdom)
In vivo determination of cardiac pyruvate dehydrogenase flux in left ventricular hypertrophy
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P.11 Justin Barnes (Birmingham, USA)
The role of PPARα in volume overload-induced heart failure
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P.13 Marcel Blumensatt (Duesseldorf, Germany)
Upregulation of miRNA-143 expression by secretory products from epicardial adipose tissue from patients with type 2 diabetes abrogates insulin action in cardiomyocytes
|
P.14 Sarah Brice (Charleston, USA)
The role of sphingolipids and (dihydro)ceramide synthase 5 in diabetic cardiomyopathy |
P.15 Heiko Bugger (Freiburg, Germany)
SIRT3 deficiency impairs cardiac function but not contractile recovery following ischemia-reperfusion
|
P.16 Fanny Caffin (Chatenay-Malabry, France)
OPA1 deficiency impairs exercise-induced mitochondrial biogenesis in skeletal muscle
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P.17 Carolyn Carr (Oxford, United Kingdom)
A high fat diet alters cardiac and adipose mesenchymal cell numbers
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P.18 Diego Castanares-Zapatero (Brussels, Belgium)
AMPK signalling pathway controls vascular permeability during sepsis in the heart
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P.19 John Chatham (Birmingham, USA)
The interplay between protein O-linked-ß-N-acetylglucosamine (O-GlcNAc) and cardiomyocyte calcium signaling
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P.20 Lowri Cochlin (Oxford, United Kingdom)
Fast 31P MRS protocol for measurement of cardiac energetics at rest and during physiological exercise stress
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P.21 Rosalind Coleman (Chapel Hill, USA)
Hearts dependent on glucose fuel have diastolic dysfunction and mTOR-responsive hypertrophy
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P.22 Christian Cortes-Rojo (Morelia, Mexico)
Avocado oil ameliorates dyslipidemia and increases the oleic acid content of aortic mitochondrial membranes from diabetic rats without improvement of the electron transport chain function
|
P.23 Sairia Dass (Oxford, United Kingdom)
Exercise acutely exacerbates derangement of cardiac energy metabolism in hypertrophic cardiomyopathy
|
P.24 Gaurang Deshpande (Cape Town, South Africa)
Glucose and insulin: emerging metabolic therapy against acute heart failure (AHF)
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P.25 Florin Despa (Davis, USA)
Cardiac amylin accumulation activates Ca2+-dependent pathways for cardiac hypertrophy
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P.26 Michael Dodd (Oxford, United Kingdom)
In vivo alterations in cardiac metabolism and function in the spontaneously hypertensive rat heart
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P.27 Sebastian Freiburger (Jena, Germany)
High fat diet induced insulin resistance in weanling sprague dawley rats
|
P.28 Sabrina Greulich (Duesseldorf, Germany)
Cardiodepressant action of the epicardial adipokine angiopoietin-2
|
P.29 Lawrence Grossman (Detroit, USA)
Mice deleted for heart/muscle-type cytochrome c oxidase subunit 7a1 develop dilated cardiomyopathy and are exercise intolerant
|
P.30 Dale Hamilton (Houston, USA)
Mitochondrial adaptation to obesity in human heart failure
|
P.31 Lisa Heather (Oxford, United Kingdom)
Fatty acid translocase/CD36 moves away from the sarcolemma and contributes to metabolic remodelling during ischemia/reperfusion in the isolated heart
|
P.32 James Horscroft (Cambridge, United Kingdom)
Angiotensin II as a modulator of mitochondrial function in rat heart and liver
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P.33 Chih-Yang Huang (Taichung, Taiwan)
Distinct roles of canonical and non-canonical macroautophagy induced by angiotensin II in H9c2 cardiomyoblast cells
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P.34 Barbara Huisamen (Tygerberg, South Africa)
DPP-4 inhibition is cardioprotective and improves glucose homeostasis in pre-diabetic rats
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P.35 Barbara Huisamen (Tygerberg, South Africa)
Cardioprotective and anti-hypertensive effects of Prosopus glandulosa in a rat model of pre-diabetes
|
P.36 Janis Kuka (Riga, Latvia)
The role of glucose and fatty acid metabolism on the outcome of cardiac ischemia-reperfusion injury
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P.37 Wei-Wen Kuo (Taichung,, Taiwan)
Diallyl Trisulfide enhances autophagy through AMPK activation and prevents apoptosis in H9c2 exposed to high glucose
|
P.38 Dominic Lachance (Montreal, Canada)
Physiological concentrations of glutamine and ketone bodies differentially modulate fatty acid trafficking in ex vivo working mouse hearts
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P.39 Dominic Lachance (Montreal, Canada)
A high fat/high fructose (HF) diet does not exacerbate the metabolic or cardiac functional consequences induced by diabetes in C57Bl6J mice
|
P.40 Mette Lauritzen (Hvidovre, Denmark)
Improving the assessment of cardiac metabolism by infusion of glucose, insulin and potassium in hyperpolarized 13C MRS studies
|
P.41 Lydia Le Page (Oxford, United Kingdom)
Real-time assessment of pharmacologically altered metabolism in the rat heart using hyperpolarised [1-13C] pyruvate
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P.42 Edgars Liepins (Riga, Latvia)
Lowered L-carnitine availability is cardioprotective through redirection of fatty acid metabolism
|
P.43 Sarah Longnus (Berne, Switzerland)
Early reperfusion hemodynamics predict recovery following cardioplegic storage in isolated rat hearts
|
P.44 Camila Lopez-Crisosto (Santiago, Chile)
Ceramides alter mitochondrial dynamics in cardiomyocytes causing insulin signaling desensibilization |
P.45 Mieke Louwe (Leiden, Netherlands)
RP105 deficiency in mice aggravates cardiac dilatation after myocardial infarction
|
P.46 Joost Luiken (Maastricht, Netherlands)
Overexpression of VAMP3 protects against lipid-induced inhibition of insulin-stimulated GLUT4 translocation in cardiomyocytes
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P.47 Craig Lygate (Oxford, United Kingdom)
Malonyl coenzyme A decarboxylase (MCD) knockout mice have impaired cardiac function and increased mortality during the peri-weaning period
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P.48 Sue Marsh (Spokane, USA)
Exercise does not alter O-linked β-N-acetylglucosamine (O-GlcNAc) protein modification in diabetic mouse hearts
|
P.49 Ruiz Matthieu (Châtenay-Malabry, France)
Steroid hormones, B vitamins and fatty acids identified as modulators of PGC-1α expression in a cardiac-like cell line
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P.50 Annika Molis (Jena, Germany)
Hyperinsulinemic euglycemic clamp – does the use of 2 different tracers affect the ability to assess whole body and isolated organ insulin sensitivity?
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P.51 Andrea Morash (Cambridge, United Kingdom)
Divergent changes in fatty acid oxidation in chronically-hypoxic heart and skeletal muscle
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P.52 Andrew Murray (Cambridge, United Kingdom)
Developmental programming of cardiac mitochondrial dysfunction by prenatal hypoxia
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P.53 Dietbert Neumann (Maastricht, Netherlands)
‘Tour de AMPK’: cycling to ameliorate type 2 diabetes?
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P.54 Dung Nguyen (Jena, Germany)
Triheptanoin-enriched diet attenuates hypertrophy and improves diastolic function and cardiac glucose oxidation in rats with pressure overload
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P.55 Philip Ostrowski (Oxford, United Kingdom)
Elevated intracellular creatine does not protect against oxidative stress but delays opening of the mitochondrial permeability transition pore in vitro
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P.56 Linda Peterson (St. Louis, USA)
Not all heart failure is metabolically the same: sex alters the shift in myocardial metabolism
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P.57 Linda Peterson (St. Louis, USA)
Patients with heart failure with preserved ejection fraction (HFpEF) have improved symptoms, exercise tolerance, diastolic function, and liver (but not cardiac) fat 3 and 6 months after gastric bypass. |
P.58 Ravichandran Ramasamy (New York, USA)
RAGE deletion promotes cardiac mitochondrial biogenesis in high fat diet fed mice
|
P.59 Santiago Reyes (Rochester, USA)
Bioengineered electrical-optical biosensors decode submembrane nucleotide dynamics
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P.60 Santiago Reyes (Rochester, USA)
KATP channel variants impact heart disease susceptibility
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P.61 Wahida Salma (Tromsø, Norway)
Wax ester purified from Calanus oil reduces visceral obesity and low-grade inflammation in adipose tissue during high fat feeding
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P.62 Michael Schwarzer (Jena, Germany)
Genetic predisposition affects the influence of exercise on insulin sensitivity
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P.63 Fareeba Sheedfar (Groningen, Netherlands)
CD36 contributes to hepatic lipid accumulation and inflammation in aged mice fed a high-fat diet
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P.64 Herman Sillje (Groningen, Netherlands)
Identification of hypertrophy and heart failure associated genes by combining in vitro and in vivo models
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P.65 Mary Slingo (Oxford, United Kingdom)
Cardiac consequences of the von Hippel-Lindau Chuvash mutation in mice
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P.66 Selene Sollie (Norway, Norway)
Dietary supplementation with Calanus oil reduces visceral fat deposition and improves insulin sensitivity during high fat feeding
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P.67 Hans Strijdom (Tygerberg, South Africa)
Regulation of the cardiac microvascular endothelial cell proteome by TNF-α stimulation
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P.68 David Taylor (Hull, United Kingdom)
Mitochondrial susceptibility to stress in uraemia
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P.69 Kelly van Bragt (Maastricht, Netherlands)
Dynamic regulation of atrial blood flow
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P.70 Michel van Weeghel (Amsterdam, Netherlands)
Initial characterization of a malonyl-CoA insensitive CPT1b KI mouse
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P.71 Xinzhu Wang (Cambridge, United Kingdom)
A metabolomics investigation of diabetic cardiomyopathy and its associated mitochondrial dysfunction
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P.72 James West (Cambridge, United Kingdom)
Application of high throughput metabolomics to a laminopathic mouse model of heart failure
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P.73 Henning Witt (Berlin, Germany)
Metabolite profiling: a promising novel diagnostic tool in heart failure
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P.74 Danielle Yancey (Birmingham, USA)
Targeting mitochondrial ROS production to prevent MMP activation and subsequent LV remodeling in volume overload
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P.75 Martin Young (Birmingham, USA)
The mitochondrial ATP-Pi transporter SLC25A25 influences myocardial ischemia/reperfusion tolerance |
P.76 Sevasti Zervou (Headington, United Kingdom)
Potential role for thioredoxin interacting protein (Txnip) in the endogenous regulation of creatine transporter activity
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P.77 Coert Zuurbier (Amsterdam, Netherlands)
Myocardial mitochondrial oxygenation is elevated in right ventricular heart failure of anesthetized rats |
P.78 Heinrich Taegtmeyer (Houston, USA)
Rapamycin relieves glucose metabolic stress in rat heart subjected to high workload ex vivo
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P.79 William Stanley (Baltimore, USA)
Glucose-6-phosphate dehydrogenase deficiency adversely affects the development of heart failure |
Registrations
16 January 2012
to
01 April 2012
Late registrations will be accepted until 21 May 2012 at a higher fee. Check the Information page for further details.
Abstracts
16 January 2012
to
01 March 2012
Notification of abstract selections will be via email on 15 March 2012.
Payment
30 January 2012
to
01 April 2012
Payment details are available through the Information page.
Organising Committee
Kieran Clarke (Co-Chair)
Oxford, UK
Stefan Neubauer (Co-Chair)
Oxford, UK
E. Dale Abel
Salt Lake City, UT
