PROGRAMME

Sunday, 4 October

5:30 p.m.

Registration

6:30 p.m.

Informal Dinner Reception

 

Monday, 5 October

8:00 a.m.

Welcome Address

Jan Glatz (SHVM President)

Ravi Ramasamy & Christian Schulze
(Co-Chairs of the Organising Committee)

 

Session I
Amino acids/protein turnover and myocardial metabolism

Chair: Jan Glatz

8:30 a.m.

Keynote Address

Alfred Goldberg (Cambridge, MA)

Functions of the proteasome in normal and disease states

9:00 a.m.

Keynote Speaker

Yibin Wang (Los Angeles, CA)

Some “sins” beyond the dessert -- amino acid metabolic reprogramming in heart failure and metabolic disorders

 

Abstracts selected for presentation

9:30 a.m.

Peter Kennel (New York, NY)

The decrease of myocardial glutamine levels in the failing myocardium is associated with the dysregulation of the neutral amino acid carrier SLC1A5

9:45 a.m.

Haipeng Sun (Los Angeles, CA)

Catabolic defect of branched-chain amino acids promotes heart failure

10:00 a.m.

Coffee Break

 

Session II
Protein modification & substrate metabolism

Chair: Michael Sack

10:30 a.m.

Keynote Speaker

Subramaniam Pennathur (Ann Arbor, MI)

Post translational modifications & substrate metabolism in diabetes

 

Abstracts selected for presentation

11:00 a.m.

Martin Young (Birmingham, AL)

Biotinylation – A novel posttranslational mechanism linking the cardiomyocyte circadian clock to cardiac metabolism

11:15 a.m.

Luc Bertrand (Brussels, Belgium)

AMP-activated protein kinase prevents cardiac hypertrophy development by inhibiting O-GlcNAcylation

12:00 noon

Lunch

1:00 p.m.

Poster Session I

 

Session III
Mitochondria & Autophagy

Chair: Christine Des Rosiers

2:00 p.m.

Keynote Speaker

Junichi Sadoshima (Newark, NJ)

Mitochondrial autophagy plays a protective role against pressure-overload- induced mitochondrial dysfunction and heart failure

 

Abstracts selected for presentation

2:30 p.m.

Monte Willis (Chapel Hill, NC)

Regulation of cardiac autophagic flux in vivo by the ubiquitin ligase Muscle Ring Finger-1 (MuRF1)

2:45 p.m.

Wenjuan Xing (Iowa City, IA)

Inducible deletion of OPA1 causes mitochondrial dysfunction and heart failure in part by mTOR – mediated suppression of autophagy

3:00 p.m.

Tea Break

 

Session IV
Lipid signaling in cardiac & skeletal muscle

Chair: Dale Abel

3:30 p.m.

Keynote Speaker

Gerald Shulman (New Haven, CT)

Role of ectopic lipid and inflammation in the pathogenesis of insulin resistance and type 2 diabetes

 

Abstracts selected for presentation

4:00 p.m.

Xianghai Liao (New Haven, CT)

Ceramide synthase-2 accelerates ceramide accumulation and lipotoxicity, mitochondrial dysfunction and insulin resistance in the failing myocardium

4:15 p.m.

Graham McGinnis (Birmingham, AL)

Differential insulin signaling as a potential cause of the metabolic shift following disruption of the cardiomyocyte circadian clock

4:30 p.m.

Poster Session II

6.30 p.m.

Dinner

 

Tuesday, 6 October

 

Session V
Transcriptional regulation of myocardial metabolism

Chair: Linda Peterson

8:30 a.m.

Keynote Address

Mukesh Jain (Cleveland, OH)

KLFs and metabolism

 

Abstracts selected for presentation

9:00 a.m.

Michael Sack (Bethesda, MD)

The post-translational control of CHOP by Parkin identified a novel regulatory control node balancing adaptive and maladaptive ER stress during pressure-overload cardiac hypertrophy

9:15 a.m.

Abhinav Diwan (St. Louis, MO)

Intermittent fasting and activation of transcription factor EB ameliorate established protein-aggregate-induced cardiomyopathy triggered by the R120G mutant αB-crystallin protein

9:30 a.m.

Adam Wende (Birmingham, AL)

Post-translational regulation of cardiac gene expression and glucose-mediated regulation of DNA methylation

9:45 a.m.

Xiaokan Zhang (New York, NY)

miR-195 Regulates Myocardial SIRT3 Expression, Mitochondrial Enzyme Acetylation and Metabolic Function in the Failing Myocardium

10:00 a.m.

Coffee Break

 

Session VI
Transcription, epigenetics & cardiac metabolism

Chair: Martin Young

10:30 a.m.

Keynote Speaker

Joseph Hill (Dallas, TX)

Diabetic cardiomyopathy: fat, FoxO, and failure

 

Early Investigator Commendation (EIC) Awardees

11:00 a.m.

Monika Rech (Maastricht, Netherlands)

miR-103/107: fine tuners of energy metabolism in the heart

11:15 a.m.

Edith Renguet (Brussels, Belgium)

Leucine and ketone bodies catabolism inhibit glucose transport in cardiomyocytes via the regulation of protein acetylation

11:30 a.m.

Yuan Zhang (Iowa City, IA)

Loss of mitochondrial pyruvate carrier 1 in cardiomyocytes leads to cardiac dysfunction and heart failure

11:45 a.m.

Miranda Sung (Edmonton, AB, Canada)

Cardiomyocyte-specific ablation of the long-chain fatty acid transporter CD36 accelerates the progression of pressure overload-induced heart failure in mice

12:00 noon

Lunch

1:00 p.m.

Poster Session III

 

Session VII
Inflammatory cells & vascular metabolism

Chair: Ellen Aasum

2:00 p.m.

Keynote Speaker

Ann Marie Schmidt (New York, NY)

Glycation & metabolic dysfunction in vascular cells

2:30 p.m.

Keynote Speaker

Merry Lindsey (Jackson, MS)

Macrophage roles in the cardiac response to injury

3:00 p.m.

Tea Break

 

Session VIII
Inter-organ signaling and cardiovascular metabolism

Chair: Jason Dyck

3:30 p.m.

Keynote Speaker

Kenneth Walsh (Boston, MA)

Inter-organ signaling and cardiovascular disease

 

Abstracts selected for presentation

4:00 p.m.

Miranda Nabben (Maastricht, Netherlands)

Metabolic adaptations in diabetes protect the murine heart from pressure overload-induced failure, as evidenced by in vivo PET, MRI, and MRS

4:15 p.m.

Anne Van Steenbergen (Brussels, Belgium)

Identification of a glucose sensor in the heart

4:30 p.m.

Poster Session IV

6:30 p.m.

Gala Dinner

Historical Perspective: Gary Lopaschuk
(Edmonton, AB, Canada)

 

Wednesday, 7 October

 

Session IX
Lipotoxicity & cardiovascular dysfunction 1

Chair: Ira Goldberg

8:30 a.m.

Keynote Address

Jean Schaffer (St. Louis, MO)

Cardiac lipotoxicity: manifestations and mechanisms

 

Abstracts selected for presentation

9:00 a.m.

Tariq Altamimi (Edmonton, AB, Canada)

Acute administration of nicotinamide mononucleotide (NMN) deacetylates FOXO1 and protects the ischemic heart independent of modifying cardiac energy metabolic rates

9:15 a.m.

Heiko Bugger (Freiburg, Germany)

LPS-induced endotoxemia impairs cardiac function and energetics due to PARP-1 activation and impaired SIRT3 activity

9:30 a.m.

Sander Houten (New York, NY)

Malonyl-CoA-dependent inhibition of Cpt1b determines cardiac fatty acid oxidation rate

9:45 a.m.

Coffee Break

 

Session X
Lipotoxicity & cardiovascular dysfunction 2

Chair: Terje Larsen

 

Abstracts selected for presentation

10:30 a.m.

Brittany Law (Charleston, SC)

Lipid oversupply to cardiomyocytes induces sphingolipid-dependent oxidative stress and induction of mitophagy through Ceramide Synthase 2

10:45 a.m.

Florencia Pascual (Chapel Hill, NC)

Cardiomyocyte-specific ACSL1 deficiency prevents cardiac lipotoxicity and alleviates heart dysfunction in two murine models of obesity

11:00 a.m.

Yilin Liu (Maastricht, Netherlands)

Causal role of the endosomal proton pump (v-ATPase) in lipid-induced insulin resistance in the heart

11:15 a.m.

Announcement of Young Investigator Oral presentation winners
 
Summary of SHVM 2015 & Introduction of SHVM 2016 Beijing Venue by Dr Dale Abel

12:00 noon

Box Lunch

 

Preparing your poster

Speakers selected from submitted abstracts should also present their data in poster format.

Please note that the maximum size of your poster is 42" (height; ~107 cm) x 60" (width; ~152 cm), in a landscape/horizontal format.

Correct format... poster should be PORTRAIT    poster should NOT be LANDSCAPE Wrong format...

 

Displaying your poster

Posters with an odd number are presented during Poster Sessions I and II, on Monday, 5 October. Posters with an even number are presented during Poster Session III and IV, on Tuesday, 6 October. The list of posters can be found in the Programme section.

You may put up your poster between 7.30 am and 8.30 am on the day of your presentation. Posters must be removed by 6.00 pm (please note that posters left in place may be removed and discarded by the venue personnel).

Authors are expected to be at their poster during both the morning and the evening sessions.

 


P.1 Dunja Aksentijevic (London, United Kingdom)
Is rate-pressure product of any use in the isolated rat heart?
Assessing cardiac ‘effort’ and oxygen consumption in the Langendorff-perfused heart
P.2 Dunja Aksentijevic (London, United Kingdom)
Metabolic consequences of the acute and chronic myocardial sodium elevation;  impact on anaplerosis?
P.3 Tariq Altamimi (Edmonton, AB, Canada)
Acute administration of nicotinamide mononucleotide (NMN) deacetylates FOXO1 and protects the ischemic heart independent of modifying cardiac energy metabolic rates
P.4 Raj Amin (Auburn, AL, USA)
The role of Frataxin in mitochnodrial iron regualtion in the diabetic heart
P.5 Luc Bertrand (Brussels, Belgium)
AMP-activated protein kinase prevents cardiac hypertrophy development by inhibiting O-GlcNAcylation
P.6 Luc Bertrand (Brussels, Belgium)
AMPK acts via OGA, OGT and GFAT to regulate O-GlcNAcylation during cardiac hypertrophy development
P.7 Indra Bole (Saint Louis, MO, USA)
Effect of acute dietary nitrate intake on measures of dyspnea in patients with heart failure with reduced ejection fraction
P.8 Manoja Brahma (Birmingham, AL, USA)
High glucose-induced protein O-GlcNAcylation and its interaction with myocardial ketone oxidation capacity
P.9 Paul Brookes (Rochester, NY, USA)
High throughput screening to identify cardioprotective drugs with a mitochondrial mechanism of action
P.10 Heiko Bugger (Freiburg, Germany)
LPS-induced endotoxemia impairs cardiac function and energetics due to PARP-1 activation and impaired SIRT3 activity
P.11 William Cade (Saint Louis, MO, USA)
Myocardial fatty acid, glucose and leucine metabolism in Barth Syndrome: a preliminary report
P.12 Florin Despa (Lexington, KY, USA)
Circulating oligomerized amylin: a molecular link of type-2 diabetes with hemorheologic and cardiac disturbances in humans
P.13 Abhinav Diwan (Saint Louis, MO, USA)
Intermittent fasting and activation of transcription factor EB ameliorate established protein-aggregate-induced cardiomyopathy triggered by the R120G mutant αB-crystallin protein
P.14 Michael Dodd (Oxford, United Kingdom)
Does type 2 diabetes affect hypoxic signaling and metabolic adaptation in the heart?
P.15 Madelene Ericsson (Umeå, Sweden)
Four weeks of very high-fat diet increases cardiac lipid content and impairs heart function in female C57Bl/6 mice
P.16 Marine Ferron (Nantes, France)
Beneficial cardiovascular effects of O-GlcNAc stimulation in early phase of septic shock
P.17 Arata Fukushima (Edmonton, AB, Canada)
Acetylation control of the maturational alterations in energy metabolism in the newborn heart
P.18 Anisha Gupte (Houston, TX, USA)
Estrogen-deficiency exacerbates mitochondrial dysfunction, oxidative stress and fibrosis to cause diastolic dysfunction
P.19 Anne Hafstad (Tromsø, Norway)
NADPH oxidase inhibition affects mitochondrial ROS production in hearts from diet-induced obese mice
P.20 Estelle Heyne (Jena, Germany)
High fat diet blunts the impact of metformin on survival and mitochondrial function in pressure overloaded rats
P.21 Sander Houten (New York, NY, USA)
Malonyl-CoA-dependent inhibition of Cpt1b determines cardiac fatty acid oxidation rate
P.22 Peter Kennel (New York, NY, USA)
The decrease of myocardial glutamine levels in the failing myocardium is associated with the dysregulation of the neutral amino acid carrier SLC1A5 
P.23 Christoph Koentges (Freiburg, Germany)
Preserved recovery of cardiac function following ischemia-reperfusion in mice lacking SIRT3
P.24 Stephen Kolwicz (Seattle, WA, USA)
Desaturation of exogenous saturated fatty acids during high fat feeding resists markers of cardiac lipotoxicity in mice
P.25 Terje Larsen (Tromsø, Norway)
Dietary Calanus oil antagonizes angiotensin II-induced hypertension and tissue wasting in diet-induced obese mice
P.26 Brittany Law (Charleston, SC, USA)
Lipid oversupply to cardiomyocytes induces sphingolipid-dependent oxidative stress and induction of mitophagy through Ceramide Synthase 2
P.27 Xianghai Liao (New York, NY, USA)
Ceramide synthase-2 accelerates ceramide accumulation and lipotoxicity, mitochondrial dysfunction and insulin resistance in the failing myocardium
P.28 Yilin Liu (Maastricht, Netherlands)
Causal role of the endosomal proton pump (v-ATPase) in lipid-induced insulin resistance in the heart
P.29 Craig Lygate (Oxford, United Kingdom)
Cardioprotective and metabolic consequences of elevating myocardial creatine
P.30 Graham McGinnis (Birmingham, AL, USA)
Differential insulin signaling as a potential cause of the metabolic shift following disruption of the cardiomyocyte circadian clock
P.31 Miranda Nabben (Maastricht, Netherlands)
Metabolic adaptations in diabetes protect the murine heart from pressure overload-induced failure, as evidenced by in vivo PET, MRI, and MRS
P.32 Tien Dung Nguyen (Jena, Germany)
A role for cardiac insulin resistance in the regulation of autophagy in pressure overload-induced hypertrophy
P.33 Karen O'Shea (New York, NY, USA)
Dysregulated glucose metabolism is linked to post translational acetylation of metabolic and antioxidant enzymes in aging hearts
P.34 Florencia Pascual (Chapel Hill, NC, USA)
Cardiomyocyte-specific ACSL1 deficiency prevents cardiac lipotoxicity and alleviates heart dysfunction in two murine models of obesity
P.35 Monika Rech (Maastricht, Netherlands)
miR-103/107: fine tuners of energy metabolism in the heart
P.36 Edith Renguet (Brussels, Belgium)
Leucine and ketone bodies catabolism inhibit glucose transport in cardiomyocytes via the regulation of protein acetylation
P.37 Edith Renguet (Brussels, Belgium)
The inhibitory action of leucine on insulin-mediated stimulation of cardiac glucose uptake does not involve the insulin negative feedback loop
P.38 Michael Sack (Bethesda, MD, USA)
The post-translational control of CHOP by Parkin identified a novel regulatory control node balancing adaptive and maladaptive ER stress during pressure-overload cardiac hypertrophy
P.39 Jonathan Schisler (Chapel Hill, NC, USA)
Acute responses of cardiac substrate switching are rescued by inhibiting mTOR activation
P.40 Andrea Schrepper (Jena, Germany)
Impact of genetic predisposition for high exercise capacity on sepsis severity and survival
P.41 Michael Schwarzer (Jena, Germany)
Effect of aerobic interval training in rats with genetically different exercise capacity on mitochondrial function
P.42 Tahnee Sente (Edegem, Belgium)
Adiponectin resistance, mitochondrial dysfunction and inflammation: a role for adiponectin receptor 1 in chronic heart failure?
P.43 Ryszard Smolenski (Gdansk, Poland)
An increase in cardiac metabolism of brached chain amino acids in atherosclerotic mice
P.44 Ni-Huiping Son (New York, NY, USA)
Fatty acid transfer across endothelial cells requires CD36
P.45 Maria da Luz Sousa Fialho (Oxford, United Kingdom)
Pharmacological inhibition of sarcolemmal fatty acid uptake as a novel mechanism to improve metabolism in the type 2 diabetic heart
P.46 Gopalkrishna Sreejit (New York, NY, USA)
Novel Role of Aldose Reductase as a selective derepressor of PPARγ and retinoic acid receptor
P.47 Haipeng Sun (Los Angeles, CA, USA)
Catabolic defect of branched-chain amino acids promotes heart failure
P.48 Miranda Sung (Edmonton, AB, Canada)
Cardiomyocyte-specific ablation of the long-chain fatty acid transporter CD36 accelerates the progression of pressure overload-induced heart failure in mice
P.49 Marta Toczek (Gdansk, Poland)
An impaired energy metabolism underlines a novel mechanism of the Huntington’s disease related cardiomyopathy
P.50 Fanny Vaillant (Pessac, France)
Acute activation of the hexosamine biosynthetic pathway promotes atrial electrical instability
P.51 Anne Van Steenbergen (Brussels, Belgium)
Identification of a glucose sensor in the heart
P.52 Abigail Washispack (Charleston, SC, USA)
Roles of Atg7 and p53 in sphingolipid-induced cardiomyocyte autophagy
P.53 Adam Wende (Birmingham, AL, USA)
Post-translational regulation of cardiac gene expression and glucose-mediated regulation of DNA methylation
P.54 Christina Werner (Jena, Germany)
Differential response to pressure overload in rats with high or low genetically determined exercise capacity
P.55 Monte Willis (Chapel Hill, NC, USA)
Regulation of cardiac autophagic flux in vivo by the ubiquitin ligase Muscle Ring Finger-1 (MuRF1)
P.56 Wenjuan Xing (Iowa City, IA, USA)
Inducible deletion of OPA1 causes mitochondrial dysfunction and heart failure in part by mTOR – mediated suppression of autophagy
P.57 Martin Young (Birmingham, AL, USA)
Biotinylation – A novel posttranslational mechanism linking the cardiomyocyte circadian clock to cardiac metabolism
P.58 Xiaokan Zhang (New York, NY, USA)
miR-195 Regulates Myocardial SIRT3 Expression, Mitochondrial Enzyme Acetylation and Metabolic Function in the Failing Myocardium
P.59 Yuan Zhang (Iowa City, IA, USA)
Loss of Mitochondrial Pyruvate Carrier 1 in Cardiomyocytes Leads to Cardiac Dysfunction and Heart Failure
P.60 Hylde Zirpoli (New York, NY, USA)
Effects of acute n-3 fatty acid treatment on cardiac Ca2+ homeostasis after myocardial ischemic injury
P.61 Raquel Lopez Diez (New York, NY, USA)
Alteration of inflammatory capacity in cardiac resident macrophages and macrophage metabolism during aging

 

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