PROGRAMME

Registration opens (Hall and Auditorium Canopee)

Opening remarks

Luc Bertrand, Christophe Beauloye (Brussels)
E. Dale Abel (Salt Lake City)

Keynote Lecture

Chair: Louis Hue (Brussels)

Christopher B. Newgard (Durham)
Metabolic profiling, a fruitful approach to understanding metabolic disorders

Followed by a walking dinner (Redwood 1)

Breakfast (Restaurant Argan)

Session I (Auditorium Baobab)

Energy metabolism in the failing heart

Chairs: Terje Larsen (Tromso) and Margaret Chandler (Cleveland)

Kieran Clarke (Oxford)
Metabolic changes in heart failure - is hypoxia involved?

Renée Ventura-Clapier (Paris)
Mitochondrial energetics in cardiac pathologies

Christine Des Rosiers (Montreal)
Metabolic alterations in heart failure patients: lessons from metabolomics

Tien Dung Nguyen (Jena)
GLP-1 preserves diastolic function and cardiac glucose oxidation and improves survival in rats with pressure overload

Lawrence Grossman (Detroit)
Mice deleted for heart-type cytochrome c oxidase subunit 7a1 develop dilated cardiomyopathy

Coffee break (E-Coffee)

Session II (Auditorium Baobab)

The failing heart - beyond metabolism

Chairs: Christophe Beauloye (Brussels) and Martin Young (Birmingham)

Ajay M. Shah (London)
ROS production and cardiac remodelling

Karin R. Sipido (Leuven)
Targeting calcium handling in cardiovascular diseases

Jean-Luc Balligand (Brussels)
Nitric oxide and cardiovascular diseases

Lunch (Restaurant Argan)

Session III (Auditorium Baobab)

Crosstalk between metabolism and cellular architecture in heart failure

Chairs: Peipei Ping (Los Angeles) and Renee Ventura-Clapier (Paris)

Yann Burelle (Montreal)
Role of dystrophin in coupling cardiac metabolism and contraction

Lawrence H. Young (Yale)
Control of myocardial cytoskeleton by AMPK

Petras Dzeja (Rochester)
Adenylate kinase 2 (AK2) deficiency disrupts mitochondrial structure, AMP metabolic signaling and metabolomic response to myocardial stress

Lisa Heather (Oxford)
Mechanisms of mitochondrial respiratory adaptation to hypoxia are determined by subcellular location

Coert Zuurbier (Amsterdam)
Mitochondrial hexokinase II is essential for cardiac function and ischemic precondiotoning

Coffee break (E-Coffee)

Session IV (Auditorium Baobab)

Metabolism and cardiac remodelling

Chairs: Jason R.b. Dyck (Edmonton) and Lawrence Young (New Haven)

William C. Stanley (Baltimore)
Structural and metabolic remodeling in cardiac hypertrophy

Wilhelm Krek (Zurich)
Hif-1α/PGC-1α pathway in pathologic cardiac hypertrophy

Magali Balteau (Brussels)
Caveolar compartimentalisation of signaling elements required for hyperglycemia-induced ROS production through NADPH oxidase in cardiomyocytes

Meiyi Zhou (Shanghai)
PP2Cm, a key regulator of branched chain amino acid catabolism, protects cardiomyocytes from stress induced cell death

Jessica Berthiaume (Cleveland)
High dietary fat promotes a normal metabolic phenotype subsequent to myocardial infarction

Poster Session I (odd numbers, Redwood 2)

Drinks (Redwood 2)

Dinner at the congress venue (Redwood 1)

Breakfast (Restaurant Argan)

Session V (Auditorium Baobab)

Control of protein metabolism in cardiac hypertrophy

Chairs: Louis Hue (Brussels) and Alexander Clanachan (Edmonton)

Christopher G. Proud (Southampton)
Role of mTORC1 in protein synthesis and autophagy

Jason R. Dyck (Edmonton)
Caloric restriction and cardiac hypertrophy

Gianluigi Condorelli (Rome)
mTOR, heart failure and cardiac hypertrophy

Coffee break (E-Coffee)

Session VI (Auditorium Baobab)

Young investigator award

Chairs: William Stanley (Baltimore) and E. Dale Abel (Salt Lake City)

Adam Wende (Salt Lake City)
Mechanisms by which glucose delivery impairs mitochondrial oxidative capacity in streptozotocin induced insulin-deficient diabetes

Roselle Gélinas (Montreal)
Mitochondrial alterations in VLCAD (very long chain acyl-CoA dehydrogenase) deficient mouse hearts

Thomas Pulinilkunnil (Edmonton)
Metabolic and functional recovery of the myocardium following ischemia-reperfusion are independent of AMPK-mediated inhibitory phosphorylation of ACC

Ellen Dirkx (Maastricht)
Protein kinase-D1 overexpression prevents lipid-induced insulin resistance and cardiomyopathy by upregulation of glucose uptake

Poster Session II (even numbers, Redwood 2)

Lunch (Restaurant Argan)

Session VII (Auditorium Baobab)

Glycolytic and non glycolytic metabolism of glucose

Chairs: Luc Bertrand (Brussels) and Jan Glatz (Maastricht)

Geoffrey D. Holman (Bath)
Exploring links between cardiac GLUT4 and NHE1 traffic

John C. Chatham (Birmingham)
O-linked glycosylation and heart diseases

Christophe Montessuit (Geneva)
How the metabolic syndrome milieu impairs myocardial glucose uptake

Free afternoon

Sightseeing tour of Brussels (optional)

Gala Dinner at the Old Royal Palace

Louis' Lecture: 30 years of cardiac metabolism

Breakfast (Restaurant Argan)

Keynote Lecture (Auditorium Baobab)

Chair: Christine Des Rosiers (Montreal)

Jean-Claude Tardif (Montreal)
HDL-based therapies for cardiovascular diseases

Session VIII (Auditorium Baobab)

Metabolism from vessels to left ventricular dysfunction

Chairs: Kieran Clarke (Oxford) and Jean-louis Vanoverschelde (Brussels)

John M. Canty (Buffalo)
Energetics in chronic hibernating myocardium

Tetsuo Shioi (Kyoto)
Role of phosphoinositide 3-kinase in cardiac aging

Coffee break (E-Coffee)

Fanny Vaillant (Montreal)
Chronic heart rate reduction in vivo with ivabradine preserves ex vivo function and glucose metabolism of working dyslipidemic mouse hearts

Florin Despa (Davis)
Patients with obesity and type-2 diabetes present cardiac IAPP accumulation - a source of cardiomyocyte Ca2+ dysregulation

Scott W. Ballinger (Birmingham)
Mitochondria and vascular function

Eric Thorin (Montreal)
Impact of heart rate reduction on vascular metabolism and function

Regine Heller (Jena)
AMPK and endothelial function

Concluding remarks

Lunch buffet (Restaurant Argan)