PROGRAMME

Registration opens (Main Lobby, Delta Lodge)

Welcome Reception (Gold/Silver Ballroom)

Breakfast (Rockies)

Opening Remarks (Gold/Silver Ballroom)
Gary Lopaschuk and Dale Abel

Keynote Lecture (Gold/Silver Ballroom)

Junichi Sadoshima (Newark, NJ, USA)
Autophagy in myocardial ischemia and heart failure

Session I (Gold/Silver Ballroom)

Lipid signalling and insulin resistance in the heart
Chairs: Gary Lopaschuk and Dale Abel

Jan Glatz (Maastricht, Netherlands)
CD36 and fate of fatty acids in heart

E. Dale Abel (Salt Lake City, UT, USA)
Insulin resistance and lipotoxicity

Brian Rodrigues (Vancouver, BC, Canada)
Fatty acid delivery to the heart following diabetes: role of lipoprotein lipase

Coffee break (Convention Foyer)

Session II (Gold/Silver Ballroom)

Young Investigator Presentations
Chairs: Michael Allard and Terje Larsen

Kalyani Bharadwaj (New York, NY, USA)
Chylomicron- and VLDL-derived fatty acids enter the heart through different pathways

Jessica Ellis (Chapel Hill, NC, USA)
Mouse cardiac acyl-CoA synthetase-1 deficiency impairs fatty acid oxidation and induces hypertrophy and mitochondrial biogenesis

Clifford Folmes (Rochester, MN, USA)
Nuclear reprogramming induces a glycolytic metabotype in induced pluripotent stem cells

Petra Caroline Kienesberger (Edmonton, AB, Canada)
Chronic reduction in cardiac triacylglycerol content promotes enhanced myocardial contractility

Lunch (Rockies)

Poster Session I (Gold/Silver Ballroom)

Session III (Gold/Silver Ballroom)
Keeping the balance: metabolic signalling in heart failure Chair: Heinrich Taegtmeyer

Genevieve Sparagna (Boulder, CO, USA)
Targeting cardiolipin with dietary treatments for heart failure

Ravichandran Ramasamy (New York, NY, USA)
Aldose reductase and myocardial ischemia-reperfusion injury

Adam Chicco (Fort Collins, CO, USA)
Role of delta-6 desaturase in aberrant cardiolipin remodeling, mitochondrial dysfunction and lipoxidative stress the failing heart

Coffee break (Convention Foyer)

Craig Lygate (Oxford, United Kingdom)
The creatine kinase system as a therapeutic target: challenges and opportunities

John Ussher (Toronto, ON, Canada)
Enhanced lifespan is malonyl CoA decarboxylase mice is associated with decreased whole body fatty acid oxidation

Dake Qi (New Haven, CT, USA)
AMP-activated protein kinase limits the activation of c-Jun N terminal kinase and prevents cardiac reperfusion injury

Monday Evening: Shuttle Departures to Boundary Ranch (parking available for those who wish to drive)

Main entrance – Delta Kananaskis Lodge (1st shuttle)

Main entrance – Delta Kananaskis Lodge (2nd shuttle)

Boundary Ranch Western Barbeque & Rodeo

Breakfast (Rockies)

Session IV (Gold/Silver Ballroom)

Insulin and hormonal signaling
Chairs: Martin Young and Margaret Chandler

Anne Murphy (San Diego, CA, USA)
Akt signaling and mitochondrial hexokinase

Ping Wang (Irvine, CA, USA)
Insulin stimulates Akt1 translocation to mitochondria and modulates oxidative phosphorylation and apoptosis in cardiac muscle

Michael Sack (Bethesda, MD, USA)
The role of protein acetylation in the interaction between mitochondrial dysfunction and insulin resistance

Sabrina Greulich (Duesseldorf, Germany)
Crosstalk between epicardial fat and the heart in patients with type 2 diabetes

Guorong Lin (Vancouver, BC, Canada)
Localization of ROCK2 in mitochondria: possible contribution to diabetic cardiomyopathy

Coffee break (Convention Foyer)

Poster Session II (Gold/Silver Ballroom)

Lunch (Rockies)

Session V (Gold/Silver Ballroom)
Protective metabolic signalling: role of the mitochondria
Chairs: Fabio Di Lisa and PeiPei Ping

Joy McCarthy (Cape Town, South Africa)
Altered fuel substrate selection required for PKCε cardioprotection

Keith Garlid (Portland, OR, USA)
Cardioprotective intramitochondrial signaling

Fabio Di Lisa (Padua, Italy)
Mitochondrial permeability transition and cardioprotection

Timothy DeGrado (Needham, MA, USA)
Imaging fatty acid oxidation in the heart

Afternoon free for Exploration and Relaxation

Evening Gala Banquet (Olympic Ballroom)

Tribute to Howard Morgan and James Neely
Gary Lopaschuk (Edmonton, AB, Canada)

Breakfast (Rockies)

Keynote Lecture (Gold/Silver Ballroom)

PeiPei Ping (Los Angeles, CA, USA)
The function and dynamics of mitochondrial proteome in cardioprotection

Session VI (Gold/Silver Ballroom)

Molecular signaling cascades involved in metabolic and growth regulation
Chairs: Brian Rodrigues and Craig Lygate

Rosalind Coleman (Chapel Hill, NC, USA)
Acyl CoA synthetase & cardiac function

Luc Bertrand (Brussels, Belgium)
Amino acid regulation of PDK1 & protein synthesis

Maria Febbraio (Cleveland, OH, USA)
Role of CD36 in Vascular Function & Atherosclerosis

David Symons (Salt Lake City, UT, USA)
Ceramide-induced impairment of endothelial nitric oxide synthase function in bovine aortic endothelial cells (BAECs) is not secondary to defective upstream signaling kinases or peroxynitrite formation

Monte Willis (Chapel Hill, NC, USA)
Cardiac Muscle Ring Finger-1 (MuRF1) alters myocardial mitochondrial capacity in vivo

Ji Li (Buffalo, NY, USA)
The cardioprotective effect of activated protein C is separate from its anticoagulant activity

Closing Remarks (Gold/Silver Ballroom)
Gary Lopaschuk, Dale Abel, and Luc Bertrand

Lunch (Rockies)